Wegovy vs Zepbound
Both FDA-approved for weight loss. Zepbound's dual-action mechanism may edge out Wegovy in head-to-head trials.
Side-by-Side Comparison
| Wegovy | Zepbound | |
|---|---|---|
| Generic Name | Semaglutide | Tirzepatide |
| Manufacturer | Novo Nordisk | Eli Lilly |
| FDA Uses | Chronic weight management, Cardiovascular risk reduction in obese adults | Chronic weight management |
| Dosing | 0.25mg escalating to 2.4mg weekly injection | 2.5mg escalating to 15mg weekly injection |
| Monthly Cost | $1,350 | $1,060 |
| With Insurance | $25–$500 | $25–$550 |
| Common Side Effects | Nausea, Diarrhea, Vomiting, Constipation, Headache | Nausea, Diarrhea, Vomiting, Constipation, Injection site reactions |
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Frequently Asked Questions
Which is better, Wegovy or Zepbound?
Both FDA-approved for weight loss. Zepbound's dual-action mechanism may edge out Wegovy in head-to-head trials. The best choice depends on your specific condition, insurance coverage, and how your body responds. Talk to your doctor about which is right for you.
Is Wegovy cheaper than Zepbound?
Wegovy costs $1,350/month while Zepbound costs $1,060/month without insurance. With insurance, copays may be similar depending on your plan's formulary.
Can I switch from Wegovy to Zepbound?
Switching between these medications should only be done under your doctor's supervision. They may need to adjust dosing and monitor for side effects during the transition.
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